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Could You Be Running Low on Glycine?
Glycine is considered a nonessential amino acid because the body can make it—but can it always make enough? Emerging evidence suggests that aging, insulin resistance, oxidative stress, and increased connective-tissue demands may create a mismatch between glycine supply and metabolic need. Learn about possible signs of glycine insufficiency, plasma amino-acid testing, glycine-rich foods, sleep dosing, collagen, glutathione, and GlyNAC.

David Stephen Klein, MD FACA FACPM
Sep 1411 min read


The Longevity Pulse: What Your Resting Heart Rate Says About Your Health
Your resting heart rate is more than just a number—it is a powerful biomarker of cardiovascular fitness, autonomic nervous system balance, metabolic health, and healthy aging. Learn why "normal" may not always mean "optimal," what research reveals about heart rate and longevity, and how exercise, sleep, nutrition, stress management, and overall health influence your pulse. Discover practical strategies to improve cardiovascular efficiency and support a longer, healthier life.

David Stephen Klein, MD FACA FACPM
Aug 1010 min read


Quercetin for Diabetes and Insulin Resistance: Could Nature's SGLT-2 Inhibitor Support Better Metabolic Health?
Quercetin is a plant compound found in onions, apples, berries, and capers. Emerging research suggests that certain forms may influence glucose absorption and some of the transport pathways associated with SGLT activity. Could this help support diabetes, insulin resistance, weight management, and metabolic health? Learn what is established, what remains theoretical, and why quercetin should complement—not replace—appropriate medical treatment.

David Stephen Klein, MD FACA FACPM
Jul 2413 min read


Adrenal Dysfunction and Adrenal Fatigue: Vital to Life, Yet Often Overlooked in Modern Medicine
The adrenal glands are among the body’s most vital yet overlooked organs, controlling stress adaptation, inflammation, blood pressure, metabolism, immune balance, and energy production. While severe adrenal failure such as Addison’s Disease is recognized in medicine, milder adrenal dysfunction often goes undiagnosed for years. Chronic stress, poor sleep, illness, medications, and nutritional deficiencies can impair adrenal function long before traditional testing reveals dise

David Stephen Klein, MD FACA FACPM
Jul 215 min read


Hashimoto’s Thyroiditis: Diagnosis, Root Causes, and Modern Treatment Strategies
Hashimoto’s thyroiditis is the most common autoimmune cause of hypothyroidism, yet many patients remain undiagnosed for years because standard thyroid testing often misses early dysfunction. Understanding the immune attack on the thyroid, the role of inflammation, nutrient deficiencies, genetics, and environmental triggers can help identify the condition sooner. Early diagnosis and targeted treatment may help restore thyroid function and improve long-term health outcomes.

David Stephen Klein, MD FACA FACPM
Jul 175 min read


Low-Grade Fever: When a Slight Temperature Elevation May Mean More Than You Think
A low-grade fever is often dismissed as insignificant, yet persistent mild elevations in body temperature may reveal important underlying physiologic stress. Infection, chronic inflammation, immune activation, endocrine dysfunction, and even hidden systemic disease can all influence temperature regulation. Understanding the body’s normal circadian temperature rhythm is equally important, since a temperature considered abnormal at one time of day may be entirely normal at anot

David Stephen Klein, MD FACA FACPM
Jul 114 min read


Can a Simple CBC Predict Future Dementia Risk?
The Monocyte-to-Lymphocyte Ratio and Its Emerging Role in Cognitive Decline. One of the cheapest test that is currently available. Can a Simple CBC Predict Future Dementia Risk? Understanding how the Monocyte-to-Lymphocyte Ratio (MLR) may reveal early inflammatory changes associated with Alzheimer’s disease, vascular dementia, and accelerated cognitive aging. Quick Look Could a routine complete blood count reveal early warning signs of future dementia? A growing body of evide

David Stephen Klein, MD FACA FACPM
Jul 75 min read


L-Glycine: An Overlooked Amino Acid for Sleep, Anxiety, Recovery, and Longevity
L-glycine is a simple amino acid with surprisingly powerful health benefits. Research suggests it may improve sleep quality, reduce anxiety, support collagen formation, enhance liver detoxification, improve metabolic health, and promote healthy aging pathways linked to longevity. Unlike conventional sedatives, glycine works naturally by supporting the body’s own restorative processes, making it one of the most overlooked compounds in nutritional and longevity medicine.

David Stephen Klein, MD FACA FACPM
Jun 275 min read


C15:0 Essential Fatty Acid: The Newly Discovered Longevity Nutrient?
For decades, nutrition science focused primarily on omega-3 and omega-6 fatty acids. New research now suggests that C15:0 (pentadecanoic acid), a naturally occurring odd-chain saturated fatty acid, may represent an overlooked essential nutrient. Early evidence indicates C15:0 may support mitochondrial function, reduce inflammation, stabilize cell membranes, improve insulin sensitivity, and potentially influence longevity pathways involved in healthy aging.

David Stephen Klein, MD FACA FACPM
Jun 185 min read


Uric Acid and Longevity: Live Longer by Keeping the Level below 5.5 mg/dl
Most people associate uric acid with gout, but emerging research suggests it may be far more important. Elevated uric acid has been linked to hypertension, cardiovascular disease, kidney disease, insulin resistance, endothelial dysfunction, and accelerated aging. While many laboratories consider levels up to 7.0 mg/dL “normal,” evidence suggests that levels below 5.5 mg/dL—and ideally near 5.0 mg/dL—may provide greater protection against vascular injury and chronic disease. U

David Stephen Klein, MD FACA FACPM
Jun 166 min read
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