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How Does Low Vitamin D Harm Kidney Function?
Creatinine is a late marker of kidney disease and often remains normal while damage is already underway. Low vitamin D contributes to early renal injury through hormonal imbalance, rising parathyroid hormone, RAAS activation, inflammation, and protein loss in the urine. These changes precede declines in GFR and explain why patients with “normal labs” may still be at significant risk for progressive kidney disease.

David Stephen Klein, MD FACA FACPM
Feb 115 min read


Can Vitamin D Supplementation Cause Kidney Damage?
Vitamin D deficiency is not simply a consequence of kidney disease—it can actively accelerate renal injury. Proper vitamin D signaling suppresses harmful hormonal pathways, protects glomerular structures, and limits fibrosis. Concerns about kidney damage stem from rare cases of vitamin D toxicity, not physiologic replacement. When dosed appropriately and monitored, vitamin D supports kidney health rather than harming it.

David Stephen Klein, MD FACA FACPM
Feb 63 min read


Vitamin D is a Hormone
Vitamin D is commonly thought of as a simple nutrient, but medically it functions as a steroid hormone with effects far beyond bone health. Unlike true vitamins, vitamin D is synthesized in the skin, activated through the liver and kidneys, and acts on receptors throughout the body to regulate gene expression. This hormonal role explains its influence on immune function, muscle strength, cardiovascular health, and brain function. Because deficiency is widespread and supplemen

David S. Klein, MD FACA FACPM
Jan 244 min read


Peptide therapy: promise, pitfalls and what patients should know
Peptides are short amino-acid chains that act as highly specific signaling molecules and have become a major class of modern therapeutics. More than 80 peptide drugs are approved worldwide, including insulin, incretin analogues such as GLP-1 receptor agonists, vasopressin analogues and linaclotide. These agents provide effective, targeted therapy in endocrine, metabolic, gastrointestinal and oncologic indications, supported by robust randomized clinical trials and rigorous ma

David S. Klein, MD FACA FACPM
Dec 5, 20258 min read


When Is Abdominal Pain An Emergency?
Abdominal Pain may be a medical emergency or it can be an experience of everyday life. Emergency or nuisance? A little insight into the decision making process is presented, here.

David S. Klein, MD FACA FACPM
Sep 22, 20255 min read


Can Raw Pumpkin Seeds Help Reduce Nighttime Bathroom Trips for BPH Sufferers ? Natural Alternative for Benign Prostatic Hypertrophy and Erectile Dysfunction
Raw Pumpkin Seeds, Shelled. Perfect 'snack' or supplement for Prostate Health The Benefits of Pumpkin Seeds for BPH, Erectile...

David S. Klein, MD FACA FACPM
Mar 6, 20254 min read


Diagnosing Urinary Tract Infections in the Elderly: PCR as Standard of Care
PCR is the standard of care in the diagnosis of urinary tract infections, particularly in the elderly and nursing home patients.

David S. Klein, MD FACA FACPM
Dec 27, 20246 min read
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