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Uric Acid and Hypertension: Is Your Uric Acid Helping Drive Your Blood Pressure?
Uric acid is best known for gout, but elevated levels are also associated with hypertension, kidney dysfunction, and cardiovascular risk. Research suggests that uric acid may influence blood pressure through oxidative stress, reduced nitric oxide, renin-angiotensin activation, renal vasoconstriction, and altered sodium handling. Learn how uric acid, kidney function, and hypertension may form a self-reinforcing cycle—and why lowering uric acid is not always the same as lowerin

David Stephen Klein, MD FACA FACPM
Aug 179 min read


Pulse Pressure, Aging, and Stroke Risk: Why the “Ideal” Number Changes With Age
Pulse pressure is the difference between systolic and diastolic blood pressure. For example, 120/80 mmHg produces a pulse pressure of 40 mmHg. Pulse pressure often widens with age as large arteries become stiffer. In older adults, a persistently wide pulse pressure may indicate increased arterial stiffness and cardiovascular risk, including stroke risk. It should be interpreted together with age, systolic and diastolic pressures, medical conditions, and overall cardiovascular

David Stephen Klein, MD FACA FACPM
Aug 149 min read


The Longevity Pulse: What Your Resting Heart Rate Says About Your Health
Your resting heart rate is more than just a number—it is a powerful biomarker of cardiovascular fitness, autonomic nervous system balance, metabolic health, and healthy aging. Learn why "normal" may not always mean "optimal," what research reveals about heart rate and longevity, and how exercise, sleep, nutrition, stress management, and overall health influence your pulse. Discover practical strategies to improve cardiovascular efficiency and support a longer, healthier life.

David Stephen Klein, MD FACA FACPM
Aug 1010 min read


C15:0 (Pentadecanoic Acid): Could This Be the First Newly Recognized Essential Fatty Acid in Nearly 100 Years?
Could C15:0 (pentadecanoic acid) become the first newly recognized essential fatty acid in nearly a century? Emerging research suggests this naturally occurring odd-chain saturated fatty acid may support healthy cell membranes, mitochondrial function, metabolic health, and healthy aging. Learn what current science tells us about food sources, supplements, recommended intake, and why researchers are paying close attention to this unique nutrient.

David Stephen Klein, MD FACA FACPM
Aug 77 min read


Pre-Diabetes: Insulin Resistance, Is It a Real Condition — Or a Warning Sign We Ignore at Our Own Risk?
Many people are told they have pre-diabetes and assume it simply means they may someday develop diabetes.
The truth is far more concerning.
Long before someone officially develops Type 2 diabetes, elevated insulin levels and subtle abnormalities in blood sugar regulation may already be damaging blood vessels, nerves, kidneys, and even the brain.
Prediabetes is not almost disease.
It is often the earliest measurable sign that metabolic dysfunction has already begun.
The g

David Stephen Klein, MD FACA FACPM
Jul 36 min read


C15:0 Essential Fatty Acid: The Newly Discovered Longevity Nutrient?
For decades, nutrition science focused primarily on omega-3 and omega-6 fatty acids. New research now suggests that C15:0 (pentadecanoic acid), a naturally occurring odd-chain saturated fatty acid, may represent an overlooked essential nutrient. Early evidence indicates C15:0 may support mitochondrial function, reduce inflammation, stabilize cell membranes, improve insulin sensitivity, and potentially influence longevity pathways involved in healthy aging.

David Stephen Klein, MD FACA FACPM
Jun 185 min read


Uric Acid and Longevity: Live Longer by Keeping the Level below 5.5 mg/dl
Most people associate uric acid with gout, but emerging research suggests it may be far more important. Elevated uric acid has been linked to hypertension, cardiovascular disease, kidney disease, insulin resistance, endothelial dysfunction, and accelerated aging. While many laboratories consider levels up to 7.0 mg/dL “normal,” evidence suggests that levels below 5.5 mg/dL—and ideally near 5.0 mg/dL—may provide greater protection against vascular injury and chronic disease. U

David Stephen Klein, MD FACA FACPM
Jun 166 min read


Vitamin E and Benefits to Human Health: More Than a Single Vitamin
Vitamin E is far more complex than many people realize. Rather than a single nutrient, vitamin E consists of multiple related compounds including tocopherols and tocotrienols, each with unique biological effects. This article reviews the different forms of vitamin E, their roles in cardiovascular, neurological, immune, and cellular health, and why high-quality supplements should contain a broad spectrum of vitamin E compounds rather than isolated alpha-tocopherol alone.

David Stephen Klein, MD FACA FACPM
May 254 min read


Bergamot Extract and Cholesterol Lowering: Natural Support for Heart Health
Bergamot is a citrus fruit increasingly studied for its potential to support healthy cholesterol levels and cardiovascular health. Rich in flavonoids and antioxidant compounds, bergamot may help reduce LDL cholesterol, triglycerides, inflammation, and oxidative stress while supporting HDL cholesterol. This article reviews the science behind bergamot, possible benefits, dosing considerations, and safety information for individuals seeking natural support for metabolic and hear

David Stephen Klein, MD FACA FACPM
May 195 min read


Insulin Resistance: The Hidden Precursor to Cardiovascular Disease, Dementia, and Accelerated Aging
Insulin resistance develops silently years before diabetes, accelerating heart disease, cognitive decline, and aging. Early detection with proper lab testing allows effective, targeted intervention to reverse risk and restore metabolic health.

David Stephen Klein, MD FACA FACPM
May 123 min read
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