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Hyperinsulinemia: The Metabolic Condition We Rarely Diagnose- but Routinely Treat Too Late
Hyperinsulinemia often precedes diabetes by decades, quietly driving heart disease, weight gain, hypertension, fatty liver disease, and accelerated aging—even when glucose levels appear normal. Early detection shifts care from reactive treatment to true prevention.

David S. Klein, MD FACA FACPM
Feb 134 min read


Microplastics and Human Health: What Medicine Is Beginning to Understand.
Microplastics and nanoplastics have emerged as a previously unrecognized but increasingly relevant source of chronic environmental exposure. Once thought to be biologically inert, these particles—derived from degraded consumer plastics and industrial materials—are now routinely detected in human blood, stool, lung tissue, placenta, breast milk, and even atherosclerotic plaques. Their presence in these tissues challenges long-standing assumptions about plastic safety and raise

David S. Klein, MD FACA FACPM
Feb 35 min read


Advanced Glycation End Products (AGEs):
Advanced glycation end products (AGEs) are biologically active compounds formed through non-enzymatic reactions between sugars and proteins, lipids, or nucleic acids. While AGE accumulation is a normal feature of aging, modern dietary patterns, insulin resistance, oxidative stress, and chronic hyperglycemia markedly accelerate their formation. Increasing evidence identifies AGEs as a central and under-recognized contributor to atherosclerotic cardiovascular disease (ASCVD) an

David S. Klein, MD FACA FACPM
Jan 164 min read


Huperzine A: Nitric Oxide for Erectile Dysfunction, Dementia. Benefits and Side Effects
Natural compounds can enhance both mental and physical performance while also protecting long-term health. One intriguing candidate is Huperzine A—an extract from the Chinese club moss Huperzia serrata. Traditionally used in Eastern medicine for memory and clarity, this alkaloid has gained attention in modern research for its role in nitric oxide (NO) signaling, neuroprotection, erectile dysfunction, and vascular function.

David S. Klein, MD FACA FACPM
Dec 26, 20256 min read


Peptide therapy: promise, pitfalls and what patients should know
Peptides are short amino-acid chains that act as highly specific signaling molecules and have become a major class of modern therapeutics. More than 80 peptide drugs are approved worldwide, including insulin, incretin analogues such as GLP-1 receptor agonists, vasopressin analogues and linaclotide. These agents provide effective, targeted therapy in endocrine, metabolic, gastrointestinal and oncologic indications, supported by robust randomized clinical trials and rigorous ma

David S. Klein, MD FACA FACPM
Dec 5, 20258 min read


Understanding the Connection Between Hypothyroidism and Atherosclerotic Heart Disease
Hypothyroidism is far more than a problem of low metabolism—it’s a quiet amplifier of vascular disease. By addressing thyroid imbalance, we not only restore energy and mental clarity but also protect the heart from atherosclerotic injury. Managing these conditions together yields the best outcomes for long-term vitality and longevity.

David S. Klein, MD FACA FACPM
Nov 13, 20255 min read


Hyaluronic Acid Supplementation: Improvement in Skin Health, Cardiac Health, Joint Health, and Vascular Health
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the human body, most notably in the skin, joints, eyes, and blood vessels. It is a key player in hydration, lubrication, and tissue integrity. As our natural levels decline with age, supplementation has gained traction in dermatology, rheumatology, ophthalmology, and beyond. Below is an overview of the many health benefits of HA supplementation, along with practical guidance for use.

David S. Klein, MD FACA FACPM
Oct 15, 20253 min read


Hyperuricemia & Cardiovascular Risk: Understanding the Connection
Uric acid is a known cause of atrial fibrillation, kidney failure and aortic aneurysm. Take appropriate steps to control this problem before the destruction progresses.

David S. Klein, MD FACA FACPM
Apr 15, 20255 min read


Fructose is the Silent Killer in the North American Diet. Inflammation, Early Death, Kidney Failure, Arthritis.
Fructose in your diet is silently killing us. I will give you a simplified overview of an enormous problem with a simple solution.

David S. Klein, MD FACA FACPM
Apr 7, 20254 min read


Exploring the Diverse World of Magnesium Chelates and Products: Pros and Cons Unveiled. Choose Intelligently
Magnesium deficiency plagues 30% of the US population. We discuss the relative advantages and subtle differences between different products

David S. Klein, MD FACA FACPM
Mar 22, 202510 min read
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