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Does Your Brain Actually Shrink During Sleep? Understanding Glymphatic Drainage. Alzheimers Prevention?
Glymphatic Drainage, Glymphatic System, Brain Health, Brain Aging, Cognitive Health, Alzheimer's Disease, Dementia Prevention, Neurodegenerative Disease, Sleep Health, Deep Sleep, Restorative Sleep, Sleep Quality, Sleep Disorders, Memory and Cognition, Healthy Aging, Longevity Medicine, Functional Medicine, Integrative Medicine, Preventive Medicine, Metabolic Health, Brain Waste Clearance, Cerebrospinal Fluid, Brain Shrinkage During Sleep, Amyloid Beta Clearance, Tau Protein,

David Stephen Klein, MD FACA FACPM
2 days ago9 min read


Can Ferrous Sulfate Raise Ferritin? When Iron Supplements Help—or Hurt. Low Ferritin?
Can ferrous sulfate raise ferritin levels? Learn how oral iron supplements replenish iron stores, how hepcidin regulates absorption, and why low ferritin may contribute to fatigue and hair loss. Discover when iron supplementation is beneficial, why increasing ferritin does not guarantee hair regrowth, and the potential risks of unnecessary iron therapy. Understanding the cause of low ferritin is essential to choosing safe, effective treatment.

David Stephen Klein, MD FACA FACPM
5 days ago9 min read


Your Ferritin May Be Low or “In Range”—But Is It Too Low for Healthy Hair?
Your ferritin may be marked “normal,” but does that mean your iron stores are adequate when you are losing hair? Iron deficiency can develop before anemia, and lower ferritin has been associated with telogen effluvium. But there is no proven universal ferritin target for hair growth—and low ferritin should not automatically mean taking iron. Learn why ferritin is a diagnostic clue, what can cause depleted iron stores, and why unexplained hair loss deserves a broader evaluatio

David Stephen Klein, MD FACA FACPM
Oct 110 min read


Your Fasting Glucose Is Normal—but Is Your Insulin?
A normal fasting glucose does not always mean normal metabolic health. During early insulin resistance, the pancreas may compensate by producing more insulin, keeping glucose deceptively normal. Measuring fasting insulin alongside glucose may reveal this hidden metabolic stress earlier. Learn why fasting insulin, HOMA-IR, A1c, triglycerides, waist circumference, and other markers can provide a more complete picture of insulin resistance and metabolic health.

David Stephen Klein, MD FACA FACPM
Sep 298 min read


Dandelion Extract for Urinary Tract Infections: An Adjunct to D-Mannose and Antibiotic Therapy
Dandelion extract may offer supportive benefits for urinary tract infections by promoting urine flow and helping the urinary tract naturally flush itself. Its role is adjunctive—not a replacement for appropriate treatment. When used alongside D-mannose, adequate hydration, and antibiotics when clinically indicated, dandelion may become part of a broader strategy for urinary health, particularly in patients with recurrent or persistent urinary symptoms.

David Stephen Klein, MD FACA FACPM
Sep 249 min read


When One Diagnosis Follows you Everywhere: The Value of an Independent Second Opinion
A second opinion is not necessarily about finding a doctor who disagrees. Shared electronic health records provide tremendous continuity, but previous diagnostic impressions may sometimes influence how later physicians approach a case. Learn about diagnostic momentum, outdated problem-list diagnoses, and why an independent second opinion may provide valuable fresh thinking when symptoms persist, treatment fails, or the diagnosis simply does not fit.

David Stephen Klein, MD FACA FACPM
Sep 2112 min read


Pepto-Bismol®: An Under-appreciated Treatment for Dyspepsia, Traveler's Diarrhea, and Foodborne Illness Prevention
Discover the evidence-based uses of Pepto-Bismol® for functional dyspepsia, traveler's diarrhea, foodborne illness, and Helicobacter pylori. Learn when it works, how to use it safely, and why this century-old medication remains an important part of modern digestive care.

David Stephen Klein, MD FACA FACPM
Aug 65 min read


Adrenal Dysfunction and Adrenal Fatigue: Vital to Life, Yet Often Overlooked in Modern Medicine
The adrenal glands are among the body’s most vital yet overlooked organs, controlling stress adaptation, inflammation, blood pressure, metabolism, immune balance, and energy production. While severe adrenal failure such as Addison’s Disease is recognized in medicine, milder adrenal dysfunction often goes undiagnosed for years. Chronic stress, poor sleep, illness, medications, and nutritional deficiencies can impair adrenal function long before traditional testing reveals dise

David Stephen Klein, MD FACA FACPM
Jul 215 min read


Lactoferrin-Rich Colostrum and Better Sleep
Quality sleep depends on far more than melatonin. Emerging research suggests that lactoferrin-rich bovine colostrum may promote restorative sleep by reducing inflammation, supporting the gut-brain axis, balancing immune function, and maintaining healthy iron metabolism. Rather than acting as a sedative, lactoferrin helps restore the biologic environment necessary for healthier sleep—and potentially healthier aging.

David Stephen Klein, MD FACA FACPM
Jul 2011 min read


Hashimoto’s Thyroiditis: Diagnosis, Root Causes, and Modern Treatment Strategies
Hashimoto’s thyroiditis is the most common autoimmune cause of hypothyroidism, yet many patients remain undiagnosed for years because standard thyroid testing often misses early dysfunction. Understanding the immune attack on the thyroid, the role of inflammation, nutrient deficiencies, genetics, and environmental triggers can help identify the condition sooner. Early diagnosis and targeted treatment may help restore thyroid function and improve long-term health outcomes.

David Stephen Klein, MD FACA FACPM
Jul 175 min read
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