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Huperzine A: Nitric Oxide for Erectile Dysfunction, Dementia. Benefits and Side Effects
Natural compounds can enhance both mental and physical performance while also protecting long-term health. One intriguing candidate is Huperzine A—an extract from the Chinese club moss Huperzia serrata. Traditionally used in Eastern medicine for memory and clarity, this alkaloid has gained attention in modern research for its role in nitric oxide (NO) signaling, neuroprotection, erectile dysfunction, and vascular function.

David S. Klein, MD FACA FACPM
Dec 26, 20256 min read


THE HIDDEN CAUSES OF PERSISTENT FATIGUE: A PHYSICIAN’S GUIDE TO OVERLOOKED METABOLIC AND ENDOCRINE DISORDERS
Chronic fatigue often signals hidden metabolic or endocrine disorders. Learn the overlooked causes—from thyroid and iron issues to insulin resistance and mitochondria.

David S. Klein, MD FACA FACPM
Dec 24, 20254 min read


The Value of Urine PCR in Diagnosing Persistent or Complicated Urinary Tract Infections
Urinary tract infections (UTIs) are traditionally diagnosed using urinalysis followed by culture and sensitivity testing. While effective in most cases, these methods may miss fastidious or slow-growing organisms, fail to identify mixed infections, or return negative results despite continued patient symptoms. Urine polymerase chain reaction (PCR) testing provides a highly sensitive molecular alternative that detects microbial DNA directly, identifies antibiotic-resistance ge

David S. Klein, MD FACA FACPM
Dec 18, 20255 min read


Surgery, Anesthesia and GLP-1 Weight Loss Medicines: The Unseen Danger
If you are preparing for surgery, one of the most important safety steps is to inform your surgeon and anesthesia team if you are taking a GLP-1 medication. These include well-known names such as Ozempic®, Wegovy®, Mounjaro®, Zepbound®, Rybelsus®, Trulicity®, Victoza®, Saxenda®, Byetta®, and Bydureon®. While these drugs provide significant benefits for weight loss and diabetes management, they can also delay stomach emptying—a normal part of their mechanism of action. In ever

David S. Klein, MD FACA FACPM
Dec 16, 20256 min read


Essential Vitamins and Supplements for Liver Health: Managing Fatty Liver Disease MASLD
Managing fatty liver disease MASLD requires a comprehensive approach. Vitamins and supplements can support liver health by reducing oxidative stress, improving metabolism, and lowering inflammation. However, they are part of a broader strategy that includes diet, exercise, and medical care.

David S. Klein, MD FACA FACPM
Dec 11, 20255 min read


Peptide therapy: promise, pitfalls and what patients should know
Peptides are short amino-acid chains that act as highly specific signaling molecules and have become a major class of modern therapeutics. More than 80 peptide drugs are approved worldwide, including insulin, incretin analogues such as GLP-1 receptor agonists, vasopressin analogues and linaclotide. These agents provide effective, targeted therapy in endocrine, metabolic, gastrointestinal and oncologic indications, supported by robust randomized clinical trials and rigorous ma

David S. Klein, MD FACA FACPM
Dec 5, 20258 min read


Have a Happy Holiday: Detox Essentials
Detoxification is often misunderstood as a fad, yet it remains a central physiological process essential for human survival. The holiday season—marked by stress, alcohol consumption, disrupted sleep, and poor dietary choices—places a substantial metabolic burden on the liver, gallbladder, kidneys, lungs, and intestinal tract. This blog outlines the science behind the body’s three-phase detox pathway and explains how targeted nutritional support can enhance natural clearance m

David S. Klein, MD FACA FACPM
Dec 2, 202510 min read


Lactoferrin Containing Colostrum: Targeted Support for Sleep, Immunity, and Respiratory Health
Lactoferrin-rich colostrum occupies a unique niche at the intersection of mucosal immunity, systemic inflammatory control, and sleep regulation. By combining the broad matrix of colostrum with the targeted antiviral, antibacterial, and immunomodulatory activity of lactoferrin, these preparations can reduce the burden of upper respiratory infections, support resilient immune function, and modestly improve sleep quality in selected populations. As with any therapeutic nutrient,

David S. Klein, MD FACA FACPM
Dec 1, 20256 min read


Zepbound® (tirzepatide) and Menopausal Weight Loss: A Promising Ally for a Challenging Transition
Menopause is a time of profound metabolic transition, and for many women, weight gain becomes an unwelcome companion despite disciplined efforts with diet and exercise. As estrogen levels fall, resting metabolism slows, visceral fat accumulates, and insulin sensitivity declines—creating a perfect storm that resists traditional weight-loss approaches. Zepbound® (tirzepatide) offers a meaningful breakthrough for women facing these challenges. By activating both GIP and GLP-1 re

David S. Klein, MD FACA FACPM
Nov 25, 20253 min read


The Link Between Estradiol and Bone Health: Preventing Osteoporosis, Osteopenia, and Dementia
By restoring estradiol through evidence-based bioidentical hormone therapy, guided by physicians experienced in integrative care, you can reduce fracture risk, sustain memory, and enhance life quality.

David S. Klein, MD FACA FACPM
Nov 20, 20255 min read
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