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Could You Be Running Low on Glycine?
Glycine is considered a nonessential amino acid because the body can make it—but can it always make enough? Emerging evidence suggests that aging, insulin resistance, oxidative stress, and increased connective-tissue demands may create a mismatch between glycine supply and metabolic need. Learn about possible signs of glycine insufficiency, plasma amino-acid testing, glycine-rich foods, sleep dosing, collagen, glutathione, and GlyNAC.

David Stephen Klein, MD FACA FACPM
Sep 1411 min read


Extreme Heat, Heavy Sweating, and Salt Loss: When Water Is Not Enough
Extreme heat and prolonged sweating cause the body to lose more than water. Sodium losses during hiking, exercise, gardening, landscaping, and outdoor work can become substantial. Learn how much salt may be lost through sweat, when water alone is sufficient, when electrolyte replacement becomes important, why drinking too much plain water can also be dangerous, and which symptoms mean it is time to stop self-treatment and seek medical care.

David Stephen Klein, MD FACA FACPM
Aug 199 min read


Low-Dose Lithium for Mild to Moderate Depression: Can a Time-Tested Mineral Improve Mood, Protect the Brain, and Promote Healthy Aging?
Could a medication long used for bipolar disorder also help support mood, protect the brain, and promote healthy aging at much lower doses? Emerging research suggests low-dose lithium may enhance neuroplasticity, reduce neuroinflammation, improve mitochondrial function, and influence pathways involved in depression and cognitive decline. Learn the current science, safety considerations, and how a systems-based evaluation may improve outcomes.

David Stephen Klein, MD FACA FACPM
Jul 2812 min read


Adrenal Dysfunction and Adrenal Fatigue: Vital to Life, Yet Often Overlooked in Modern Medicine
The adrenal glands are among the body’s most vital yet overlooked organs, controlling stress adaptation, inflammation, blood pressure, metabolism, immune balance, and energy production. While severe adrenal failure such as Addison’s Disease is recognized in medicine, milder adrenal dysfunction often goes undiagnosed for years. Chronic stress, poor sleep, illness, medications, and nutritional deficiencies can impair adrenal function long before traditional testing reveals dise

David Stephen Klein, MD FACA FACPM
Jul 215 min read


Pre-Diabetes: Insulin Resistance, Is It a Real Condition — Or a Warning Sign We Ignore at Our Own Risk?
Many people are told they have pre-diabetes and assume it simply means they may someday develop diabetes.
The truth is far more concerning.
Long before someone officially develops Type 2 diabetes, elevated insulin levels and subtle abnormalities in blood sugar regulation may already be damaging blood vessels, nerves, kidneys, and even the brain.
Prediabetes is not almost disease.
It is often the earliest measurable sign that metabolic dysfunction has already begun.
The g

David Stephen Klein, MD FACA FACPM
Jul 36 min read


The Healing Power of Nourishment: Food as Medicine in Everyday Life
Let Food be thy medicine and Medicine be thy food. Food is more than fuel—it is biologically active. Learn how everyday foods reduce inflammation, support heart and brain health, and influence long-term wellness. This physician-guided overview explains how to use nutrition as a practical tool for disease prevention and improved vitality.

David S. Klein, MD FACA FACPM
Mar 294 min read


What Is an Antioxidant—and Why Are Antioxidants Important?
Antioxidants are essential biological protectors that help maintain cellular integrity by neutralizing harmful molecules known as free radicals. Free radicals are produced naturally during metabolism and play limited roles in immune defense and cell signaling. However, when their production exceeds the body’s protective capacity—a state known as oxidative stress—they can damage cell membranes, proteins, mitochondria, and DNA. Over time, this damage contributes to aging and ma

David S. Klein, MD FACA FACPM
Mar 246 min read


Iodine, Selenium, and Thyroid Function: Why Balance Matters
https://mayoclinic.elsevierpure.com/en/publications/selenium-and-graves-disease/

David Stephen Klein, MD FACA FACPM
Mar 215 min read


Selenium, Thyroid Autoimmunity, and Hypothyroidism. Why This Trace Mineral Matters for Thyroid Health
Selenium plays a crucial role in thyroid hormone metabolism and immune regulation. This trace mineral supports the conversion of T4 to active T3 and protects thyroid tissue from oxidative stress. In autoimmune thyroiditis, selenium may help reduce thyroid antibody levels and stabilize thyroid function. Learn where selenium occurs in food, the role of selenomethionine, and safe supplementation levels for thyroid support.

David Stephen Klein, MD FACA FACPM
Mar 195 min read


Magnesium Deficiency: The Most Common Mineral Deficiency. What Does it Do?
Magnesium deficiency is common and often missed. Low magnesium contributes to arrhythmias, insulin resistance, anxiety, and metabolic dysfunction—frequently despite “normal” serum labs. Learn how magnesium affects cardiac stability, insulin signaling, and neuroexcitation, and why correcting intracellular deficiency may improve cardiometabolic and neurologic health.

David Stephen Klein, MD FACA FACPM
Feb 204 min read
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