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Does Your Brain Actually Shrink During Sleep? Understanding Glymphatic Drainage. Alzheimers Prevention?
Glymphatic Drainage, Glymphatic System, Brain Health, Brain Aging, Cognitive Health, Alzheimer's Disease, Dementia Prevention, Neurodegenerative Disease, Sleep Health, Deep Sleep, Restorative Sleep, Sleep Quality, Sleep Disorders, Memory and Cognition, Healthy Aging, Longevity Medicine, Functional Medicine, Integrative Medicine, Preventive Medicine, Metabolic Health, Brain Waste Clearance, Cerebrospinal Fluid, Brain Shrinkage During Sleep, Amyloid Beta Clearance, Tau Protein,

David Stephen Klein, MD FACA FACPM
2 days ago9 min read


Why Do My Eyes Twitch? Common Causes, Deficiencies, and Warning Signs: part 1
Why do my eyes twitch? Eyelid twitching, medically known as myokymia, is usually harmless but can be frustrating. Common triggers include stress, poor sleep, caffeine, dry eyes, and ocular irritation. Although magnesium deficiency is often suspected, it is rarely the proven cause. Learn what causes involuntary eyelid spasms, how to relieve them, and which warning signs may indicate an underlying neurological condition requiring medical evaluation.

David Stephen Klein, MD FACA FACPM
Oct 158 min read


Lactoferrin-Rich Colostrum and Better Sleep
Quality sleep depends on far more than melatonin. Emerging research suggests that lactoferrin-rich bovine colostrum may promote restorative sleep by reducing inflammation, supporting the gut-brain axis, balancing immune function, and maintaining healthy iron metabolism. Rather than acting as a sedative, lactoferrin helps restore the biologic environment necessary for healthier sleep—and potentially healthier aging.

David Stephen Klein, MD FACA FACPM
Jul 2011 min read


Low-Grade Fever: When a Slight Temperature Elevation May Mean More Than You Think
A low-grade fever is often dismissed as insignificant, yet persistent mild elevations in body temperature may reveal important underlying physiologic stress. Infection, chronic inflammation, immune activation, endocrine dysfunction, and even hidden systemic disease can all influence temperature regulation. Understanding the body’s normal circadian temperature rhythm is equally important, since a temperature considered abnormal at one time of day may be entirely normal at anot

David Stephen Klein, MD FACA FACPM
Jul 114 min read


L-Glycine: An Overlooked Amino Acid for Sleep, Anxiety, Recovery, and Longevity
L-glycine is a simple amino acid with surprisingly powerful health benefits. Research suggests it may improve sleep quality, reduce anxiety, support collagen formation, enhance liver detoxification, improve metabolic health, and promote healthy aging pathways linked to longevity. Unlike conventional sedatives, glycine works naturally by supporting the body’s own restorative processes, making it one of the most overlooked compounds in nutritional and longevity medicine.

David Stephen Klein, MD FACA FACPM
Jun 275 min read


How Room Humidity Affects Sleep Quality: An Overlooked Variable in Restorative Sleep
Most people focus on sleep duration, mattress quality, or circadian rhythm when trying to improve sleep. Few realize that bedroom humidity can profoundly influence airway comfort, thermoregulation, snoring, sleep fragmentation, and even overnight hormone balance. Maintaining proper humidity may be one of the simplest and least appreciated interventions for improving restorative sleep.

David S. Klein, MD FACA FACPM
Jun 235 min read


Why Do I Wake Up at 3 AM Every Night? "3 a.m. Awakening"
Do you find yourself waking up around 3 AM night after night and struggling to fall back asleep? You're not alone. While occasional awakenings are normal, consistently waking during the early morning hours may signal an imbalance in cortisol, blood sugar regulation, stress hormones, sleep architecture, or circadian rhythm function. Understanding why this happens can provide important clues about your overall health. In this article, we'll explore the common causes of 3 AM awa

David Stephen Klein, MD FACA FACPM
Jun 65 min read


Is It the Cause… or Just a Coincidence? Understanding Why Not Every Imaging Finding Explains Your Symptoms
Not every abnormal finding on an MRI or X-ray explains your symptoms. Many changes in the body are part of normal aging and may be coincidental. Understanding the difference between causal and incidental findings is essential before considering surgery or invasive treatments. A thoughtful, patient-centered approach ensures that care is directed at the true source of symptoms—not just what appears abnormal on imaging.

David Stephen Klein, MD FACA FACPM
Mar 255 min read


Seasonal Affective Disorder
Seasonal affective disorder is not simply “winter blues,” but a biologically driven condition caused by reduced light exposure and circadian disruption. Shortened daylight alters melatonin, serotonin, and cortisol signaling, leading to fatigue, low mood, sleep disturbance, and cognitive slowing. When recognized early and treated with targeted light therapy, vitamin D repletion, and circadian-based interventions, seasonal affective disorder is highly manageable and often fully

David Stephen Klein, MD FACA FACPM
Feb 284 min read


Overfunctioning: When Competence Becomes a Coping Strategy
Overfunctioning is not a psychiatric diagnosis but a behavioral pattern rooted in adaptation. It can create stability, achievement, and leadership—yet when rigid or chronic, it fuels burnout, resentment, and physiologic stress. This article explores how overfunctioning becomes harmful, how it affects relationships and stress hormones, and how to restore flexibility without sacrificing competence.

David Stephen Klein, MD FACA FACPM
Feb 285 min read
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