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Fatty Liver Disease (MASLD): The Metabolic Warning Sign of Insulin Resistance
Metabolic dysfunction–associated steatotic liver disease (MASLD), formerly called fatty liver, is not a liver problem alone—it is a systemic marker of insulin resistance. Often silent for years, MASLD signals elevated cardiometabolic, cognitive, and longevity risk long before abnormal liver enzymes or diabetes appear.

David S. Klein, MD FACA FACPM
7 days ago3 min read


Insulin Resistance: The Hidden Precursor to Cardiovascular Disease, Dementia, and Accelerated Aging
Insulin resistance often develops years before diabetes, heart disease, or dementia are diagnosed. During this silent phase, metabolic dysfunction damages blood vessels, the brain, and cellular aging pathways. Understanding insulin resistance early allows for targeted intervention that can meaningfully reduce cardiovascular risk, cognitive decline, and accelerated biological aging.

David S. Klein, MD FACA FACPM
Feb 93 min read


Essential Vitamins and Supplements for Liver Health: Managing Fatty Liver Disease MASLD
Managing fatty liver disease MASLD requires a comprehensive approach. Vitamins and supplements can support liver health by reducing oxidative stress, improving metabolism, and lowering inflammation. However, they are part of a broader strategy that includes diet, exercise, and medical care.

David S. Klein, MD FACA FACPM
Dec 11, 20255 min read


Peptide therapy: promise, pitfalls and what patients should know
Peptides are short amino-acid chains that act as highly specific signaling molecules and have become a major class of modern therapeutics. More than 80 peptide drugs are approved worldwide, including insulin, incretin analogues such as GLP-1 receptor agonists, vasopressin analogues and linaclotide. These agents provide effective, targeted therapy in endocrine, metabolic, gastrointestinal and oncologic indications, supported by robust randomized clinical trials and rigorous ma

David S. Klein, MD FACA FACPM
Dec 5, 20258 min read


Have a Happy Holiday: Detox Essentials
Detoxification is often misunderstood as a fad, yet it remains a central physiological process essential for human survival. The holiday season—marked by stress, alcohol consumption, disrupted sleep, and poor dietary choices—places a substantial metabolic burden on the liver, gallbladder, kidneys, lungs, and intestinal tract. This blog outlines the science behind the body’s three-phase detox pathway and explains how targeted nutritional support can enhance natural clearance m

David S. Klein, MD FACA FACPM
Dec 2, 202510 min read


Zepbound® (tirzepatide) and Menopausal Weight Loss: A Promising Ally for a Challenging Transition
Menopause is a time of profound metabolic transition, and for many women, weight gain becomes an unwelcome companion despite disciplined efforts with diet and exercise. As estrogen levels fall, resting metabolism slows, visceral fat accumulates, and insulin sensitivity declines—creating a perfect storm that resists traditional weight-loss approaches. Zepbound® (tirzepatide) offers a meaningful breakthrough for women facing these challenges. By activating both GIP and GLP-1 re

David S. Klein, MD FACA FACPM
Nov 25, 20253 min read


The Link Between Fructose Beverages and Non-Alcoholic Fatty Liver Disease
Understanding the connection between fructose-containing beverages and fatty liver disease empowers people to make informed choices. By reducing sugary drink intake and adopting healthier habits, it is possible to protect the liver and improve overall health.

David S. Klein, MD FACA FACPM
Nov 10, 20255 min read


Hyaluronic Acid Supplementation: Improvement in Skin Health, Cardiac Health, Joint Health, and Vascular Health
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the human body, most notably in the skin, joints, eyes, and blood vessels. It is a key player in hydration, lubrication, and tissue integrity. As our natural levels decline with age, supplementation has gained traction in dermatology, rheumatology, ophthalmology, and beyond. Below is an overview of the many health benefits of HA supplementation, along with practical guidance for use.

David S. Klein, MD FACA FACPM
Oct 15, 20253 min read


GLP-1 Medications and Dementia Prevention. Weight Loss, Diabetes Risk Reduction and Alzheimer's Prevention, as a Bonus!
Popular GLP-1 medications, like Ozempic and Zepbound may provide prevention of Alzheimer's Dementia on top of the weight reduction and diabetes control.
Reduction of weight helps with Sleep Apnea, as well. Understand the need for medical monitoring if you are going to use these medications.
This is a worthy read to give a comprehensive presentation as to the risks/benefits as well as the need for vigilance.

David S. Klein, MD FACA FACPM
Sep 23, 202512 min read


Your Statin Medication May be Increasing your Risk of Alzheimer's Dementia, Raising your Risk of Diabetes and may be making it harder to lose weight. Learn more....
Statin medications may lower your cholesterol but the cost to you may be increased risk of dementia, worsening of your diabetes and increased weight gain.

David S. Klein, MD FACA FACPM
Sep 19, 20258 min read
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