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Low-Grade Fever: When a Slight Temperature Elevation May Mean More Than You Think
A low-grade fever is often dismissed as insignificant, yet persistent mild elevations in body temperature may reveal important underlying physiologic stress. Infection, chronic inflammation, immune activation, endocrine dysfunction, and even hidden systemic disease can all influence temperature regulation. Understanding the body’s normal circadian temperature rhythm is equally important, since a temperature considered abnormal at one time of day may be entirely normal at anot

David Stephen Klein, MD FACA FACPM
Jul 114 min read


Uric Acid and Longevity: Live Longer by Keeping the Level below 5.5 mg/dl
Most people associate uric acid with gout, but emerging research suggests it may be far more important. Elevated uric acid has been linked to hypertension, cardiovascular disease, kidney disease, insulin resistance, endothelial dysfunction, and accelerated aging. While many laboratories consider levels up to 7.0 mg/dL “normal,” evidence suggests that levels below 5.5 mg/dL—and ideally near 5.0 mg/dL—may provide greater protection against vascular injury and chronic disease. U

David Stephen Klein, MD FACA FACPM
Jun 166 min read


What Is Sepsis? Recognizing the Symptoms and Early Signs of a Life-Threatening Infection
Sepsis is a life-threatening condition caused by the body’s extreme response to infection. Learn the early warning signs, risk factors, and why rapid treatment is critical to prevent organ failure and save lives.

David Stephen Klein, MD FACA FACPM
May 15 min read


Sepsis and the Urinary Tract: Why Diagnosis Fails—And How We Fix It
Sepsis frequently originates from urinary infections in older adults, yet diagnosis is often flawed. Routine dipsticks can miss true infection and overcall colonization. This article explains the limitations of traditional testing and introduces a more accurate strategy: urinalysis with culture, followed by PCR when needed. Early recognition and improved diagnostics can significantly alter outcomes.

David Stephen Klein, MD FACA FACPM
Apr 295 min read


Bacteria in the Urine: When Not Treating Is Safe—And When It Is Not
Bacteria in the urine does not always require treatment—but failing to treat a true infection can be dangerous. This article explains when bacteriuria can be safely observed and when it must be treated to prevent complications such as kidney infection, bacteremia, and sepsis.

David Stephen Klein, MD FACA FACPM
Apr 174 min read


How Does Low Vitamin D Harm Kidney Function?
Creatinine is a late marker of kidney disease and often remains normal while damage is already underway. Low vitamin D contributes to early renal injury through hormonal imbalance, rising parathyroid hormone, RAAS activation, inflammation, and protein loss in the urine. These changes precede declines in GFR and explain why patients with “normal labs” may still be at significant risk for progressive kidney disease.

David Stephen Klein, MD FACA FACPM
Feb 115 min read


Can Vitamin D Supplementation Cause Kidney Damage?
Vitamin D deficiency is not simply a consequence of kidney disease—it can actively accelerate renal injury. Proper vitamin D signaling suppresses harmful hormonal pathways, protects glomerular structures, and limits fibrosis. Concerns about kidney damage stem from rare cases of vitamin D toxicity, not physiologic replacement. When dosed appropriately and monitored, vitamin D supports kidney health rather than harming it.

David Stephen Klein, MD FACA FACPM
Feb 63 min read


The Value of Urine PCR in Diagnosing Persistent or Complicated Urinary Tract Infections
Urinary tract infections (UTIs) are traditionally diagnosed using urinalysis followed by culture and sensitivity testing. While effective in most cases, these methods may miss fastidious or slow-growing organisms, fail to identify mixed infections, or return negative results despite continued patient symptoms. Urine polymerase chain reaction (PCR) testing provides a highly sensitive molecular alternative that detects microbial DNA directly, identifies antibiotic-resistance ge

David S. Klein, MD FACA FACPM
Dec 18, 20255 min read


Exploring the Complexities of Urinary Tract Infections (UTI) in Adults and Elderly Patients.
Urinary tract infections (UTIs) are one of the most common infections among adults and elderly patients, impacting their health and...

David S. Klein, MD FACA FACPM
Mar 14, 20257 min read


Can Raw Pumpkin Seeds Help Reduce Nighttime Bathroom Trips for BPH Sufferers ? Natural Alternative for Benign Prostatic Hypertrophy and Erectile Dysfunction
Raw Pumpkin Seeds, Shelled. Perfect 'snack' or supplement for Prostate Health The Benefits of Pumpkin Seeds for BPH, Erectile...

David S. Klein, MD FACA FACPM
Mar 6, 20254 min read
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