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Does Your Brain Actually Shrink During Sleep? Understanding Glymphatic Drainage. Alzheimers Prevention?
Glymphatic Drainage, Glymphatic System, Brain Health, Brain Aging, Cognitive Health, Alzheimer's Disease, Dementia Prevention, Neurodegenerative Disease, Sleep Health, Deep Sleep, Restorative Sleep, Sleep Quality, Sleep Disorders, Memory and Cognition, Healthy Aging, Longevity Medicine, Functional Medicine, Integrative Medicine, Preventive Medicine, Metabolic Health, Brain Waste Clearance, Cerebrospinal Fluid, Brain Shrinkage During Sleep, Amyloid Beta Clearance, Tau Protein,

David Stephen Klein, MD FACA FACPM
2 days ago9 min read


What Is a Tremor? Understanding Why We Shake and What the Pattern Can Tell Us
A tremor is an involuntary, rhythmic shaking movement—but it is a symptom, not a diagnosis. Tremors may occur at rest, during movement, while holding a position, or when contracting muscles against resistance. Causes range from stress, caffeine, and medications to essential tremor, Parkinson’s disease, metabolic disorders, and other neurologic conditions. Understanding when and how the shaking occurs can provide an important clue to what is causing it.

David Stephen Klein, MD FACA FACPM
Oct 914 min read


The Long Shadow of Influenza: Can the Flu Affect the Brain Decades Later? Trigger Dementia?
Influenza usually lasts days or weeks—but could its effects on the brain last much longer? From von Economo's mysterious encephalitis lethargica to modern research linking severe infections with neuroinflammation and later dementia, scientists are reconsidering the long-term neurologic consequences of infection. The evidence does not prove that influenza causes dementia, but it raises an important question: can infection alter the trajectory of an aging brain?

David Stephen Klein, MD FACA FACPM
Oct 713 min read


Low-Dose Lithium for Mild to Moderate Depression: Can a Time-Tested Mineral Improve Mood, Protect the Brain, and Promote Healthy Aging?
Could a medication long used for bipolar disorder also help support mood, protect the brain, and promote healthy aging at much lower doses? Emerging research suggests low-dose lithium may enhance neuroplasticity, reduce neuroinflammation, improve mitochondrial function, and influence pathways involved in depression and cognitive decline. Learn the current science, safety considerations, and how a systems-based evaluation may improve outcomes.

David Stephen Klein, MD FACA FACPM
Jul 2812 min read


Alpha-Lipoic Acid: A Powerful Tool for Metabolic Health, Weight Loss, Insulin Resistance and Brain Protection
Alpha-lipoic acid (ALA) is a powerful antioxidant that plays an important role in metabolism, weight management, and brain health. Research shows it may improve insulin sensitivity, support healthy blood sugar regulation, promote fat metabolism, and help protect against cognitive decline by reducing oxidative stress and improving mitochondrial function. For patients focused on longevity and prevention, ALA may represent one of the most versatile evidence-based nutritional int

David Stephen Klein, MD FACA FACPM
Jul 165 min read


L-Glycine: An Overlooked Amino Acid for Sleep, Anxiety, Recovery, and Longevity
L-glycine is a simple amino acid with surprisingly powerful health benefits. Research suggests it may improve sleep quality, reduce anxiety, support collagen formation, enhance liver detoxification, improve metabolic health, and promote healthy aging pathways linked to longevity. Unlike conventional sedatives, glycine works naturally by supporting the body’s own restorative processes, making it one of the most overlooked compounds in nutritional and longevity medicine.

David Stephen Klein, MD FACA FACPM
Jun 275 min read


Vitamin D in Midlife May Reduce Future Tau Protein Burden: Implications for Dementia Prevention
A major new study published in Neurology demonstrated that individuals with higher circulating vitamin D levels during midlife showed significantly lower tau protein accumulation in the brain nearly two decades later. Tau protein accumulation is one of the central pathological hallmarks of Alzheimer’s disease and other neurodegenerative disorders. These findings suggest vitamin D optimization during midlife may represent an overlooked but potentially powerful intervention for

David Stephen Klein, MD FACA FACPM
Jun 156 min read


Insulin Resistance: The Hidden Precursor to Cardiovascular Disease, Dementia, and Accelerated Aging
Insulin resistance develops silently years before diabetes, accelerating heart disease, cognitive decline, and aging. Early detection with proper lab testing allows effective, targeted intervention to reverse risk and restore metabolic health.

David Stephen Klein, MD FACA FACPM
May 123 min read


What Is Sepsis? Recognizing the Symptoms and Early Signs of a Life-Threatening Infection
Sepsis is a life-threatening condition caused by the body’s extreme response to infection. Learn the early warning signs, risk factors, and why rapid treatment is critical to prevent organ failure and save lives.

David Stephen Klein, MD FACA FACPM
May 15 min read


Sepsis and the Urinary Tract: Why Diagnosis Fails—And How We Fix It
Sepsis frequently originates from urinary infections in older adults, yet diagnosis is often flawed. Routine dipsticks can miss true infection and overcall colonization. This article explains the limitations of traditional testing and introduces a more accurate strategy: urinalysis with culture, followed by PCR when needed. Early recognition and improved diagnostics can significantly alter outcomes.

David Stephen Klein, MD FACA FACPM
Apr 295 min read
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