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Peptide therapy: promise, pitfalls and what patients should know
Peptides are short amino-acid chains that act as highly specific signaling molecules and have become a major class of modern therapeutics. More than 80 peptide drugs are approved worldwide, including insulin, incretin analogues such as GLP-1 receptor agonists, vasopressin analogues and linaclotide. These agents provide effective, targeted therapy in endocrine, metabolic, gastrointestinal and oncologic indications, supported by robust randomized clinical trials and rigorous ma

David S. Klein, MD FACA FACPM
Dec 5, 20258 min read


Have a Happy Holiday: Detox Essentials
Detoxification is often misunderstood as a fad, yet it remains a central physiological process essential for human survival. The holiday season—marked by stress, alcohol consumption, disrupted sleep, and poor dietary choices—places a substantial metabolic burden on the liver, gallbladder, kidneys, lungs, and intestinal tract. This blog outlines the science behind the body’s three-phase detox pathway and explains how targeted nutritional support can enhance natural clearance m

David S. Klein, MD FACA FACPM
Dec 2, 202510 min read


Zepbound® (tirzepatide) and Menopausal Weight Loss: A Promising Ally for a Challenging Transition
Menopause is a time of profound metabolic transition, and for many women, weight gain becomes an unwelcome companion despite disciplined efforts with diet and exercise. As estrogen levels fall, resting metabolism slows, visceral fat accumulates, and insulin sensitivity declines—creating a perfect storm that resists traditional weight-loss approaches. Zepbound® (tirzepatide) offers a meaningful breakthrough for women facing these challenges. By activating both GIP and GLP-1 re

David S. Klein, MD FACA FACPM
Nov 25, 20253 min read


Understanding the Connection Between Hypothyroidism and Atherosclerotic Heart Disease
Hypothyroidism is far more than a problem of low metabolism—it’s a quiet amplifier of vascular disease. By addressing thyroid imbalance, we not only restore energy and mental clarity but also protect the heart from atherosclerotic injury. Managing these conditions together yields the best outcomes for long-term vitality and longevity.

David S. Klein, MD FACA FACPM
Nov 13, 20255 min read


Hyaluronic Acid Supplementation: Improvement in Skin Health, Cardiac Health, Joint Health, and Vascular Health
Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan found throughout the human body, most notably in the skin, joints, eyes, and blood vessels. It is a key player in hydration, lubrication, and tissue integrity. As our natural levels decline with age, supplementation has gained traction in dermatology, rheumatology, ophthalmology, and beyond. Below is an overview of the many health benefits of HA supplementation, along with practical guidance for use.

David S. Klein, MD FACA FACPM
Oct 15, 20253 min read


An Unexplored Connection: The Impact of Elevated Uric Acid Levels on Atrial Fibrillation Development
Atrial fibrillation (AF) is a common form of irregular heartbeat that can lead to severe complications, including stroke and heart...

David S. Klein, MD FACA FACPM
Apr 18, 20258 min read


Hyperuricemia & Cardiovascular Risk: Understanding the Connection
Uric acid is a known cause of atrial fibrillation, kidney failure and aortic aneurysm. Take appropriate steps to control this problem before the destruction progresses.

David S. Klein, MD FACA FACPM
Apr 15, 20255 min read


The Glycocalyx: The Largely Unrecognized Center of Cardiac, Kidney and Gut Illness. This may be the most important piece of medical trivia that you need to know.
The Glycocalyx is the lining layer within the blood vessels and the gut. It is easily damaged and it becomes the epicenter of pathology that shortens life span, decreases health and it is easily maintained to prevent heart disease and stroke.

David S. Klein, MD FACA FACPM
Apr 11, 20257 min read


Fructose is the Silent Killer in the North American Diet. Inflammation, Early Death, Kidney Failure, Arthritis.
Fructose in your diet is silently killing us. I will give you a simplified overview of an enormous problem with a simple solution.

David S. Klein, MD FACA FACPM
Apr 7, 20254 min read


Outside the Box Thinking on What Might Contribute to Alzheimer's Dementia: The Glycocalyx. The Structure and Function of the Glycocalyx and Its Connection With Blood-Brain Barrier.
An interesting article that may enlighten us as to what might be going wrong leading to dementia.

David S. Klein, MD FACA FACPM
Mar 5, 20254 min read
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