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Uric Acid and Longevity: Live Longer by Keeping the Level below 5.5 mg/dl
Most people associate uric acid with gout, but emerging research suggests it may be far more important. Elevated uric acid has been linked to hypertension, cardiovascular disease, kidney disease, insulin resistance, endothelial dysfunction, and accelerated aging. While many laboratories consider levels up to 7.0 mg/dL “normal,” evidence suggests that levels below 5.5 mg/dL—and ideally near 5.0 mg/dL—may provide greater protection against vascular injury and chronic disease. U

David Stephen Klein, MD FACA FACPM
2 days ago6 min read


Metabolic Syndrome: The Clinical Turning Point You Can Still Reverse
Metabolic syndrome marks the point where insulin resistance becomes measurable disease. At this stage, the process remains highly reversible. Early detection and targeted intervention can prevent progression to heart disease, diabetes, and cognitive decline.

David Stephen Klein, MD FACA FACPM
May 143 min read


Insulin Resistance: The Hidden Precursor to Cardiovascular Disease, Dementia, and Accelerated Aging
Insulin resistance develops silently years before diabetes, accelerating heart disease, cognitive decline, and aging. Early detection with proper lab testing allows effective, targeted intervention to reverse risk and restore metabolic health.

David Stephen Klein, MD FACA FACPM
May 123 min read


Advanced Glycation End Products (AGEs):
Advanced glycation end products (AGEs) are biologically active compounds formed through non-enzymatic reactions between sugars and proteins, lipids, or nucleic acids. While AGE accumulation is a normal feature of aging, modern dietary patterns, insulin resistance, oxidative stress, and chronic hyperglycemia markedly accelerate their formation. Increasing evidence identifies AGEs as a central and under-recognized contributor to atherosclerotic cardiovascular disease (ASCVD) an

David S. Klein, MD FACA FACPM
Jan 164 min read


Understanding the Connection Between Hypothyroidism and Atherosclerotic Heart Disease
Hypothyroidism is far more than a problem of low metabolism—it’s a quiet amplifier of vascular disease. By addressing thyroid imbalance, we not only restore energy and mental clarity but also protect the heart from atherosclerotic injury. Managing these conditions together yields the best outcomes for long-term vitality and longevity.

David S. Klein, MD FACA FACPM
Nov 13, 20255 min read
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