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The Genetic Hand You're Dealt: Life Is a Game of Five-Card Poker. Genetics and Epigenetics
Your genes are like the cards you're dealt in a poker game. Some people inherit a greater risk of diabetes, heart disease, Alzheimer's, or cancer, but genetic predisposition does not guarantee disease. Diet, sleep, stress, trauma, environmental exposures, and epigenetic regulation can influence how inherited risks unfold. Discover how everyday choices may change the odds of chronic disease and premature aging. A genetic predisposition is a reason for vigilance, not a declarat

David Stephen Klein, MD FACA FACPM
19 hours ago9 min read


PCOS, Polycystic ovary syndrome: Why Insulin and Testosterone Matter:
Polycystic ovary syndrome (PCOS) is more than an ovarian disorder. Insulin resistance, elevated insulin, and excessive testosterone frequently interact to disrupt ovulation and metabolic health. But is PCOS sometimes overdiagnosed? Learn why ovarian ultrasound findings alone are insufficient, how insulin and testosterone testing can clarify the clinical picture, and why an accurate diagnosis requires excluding other endocrine disorders.

David Stephen Klein, MD FACA FACPM
3 days ago12 min read


Glymphatic Drainage, Alzheimer's Disease, and How to Protect Your Brain. part 2
Does your brain actually shrink while you sleep? Scientists have discovered that spaces between brain cells may expand during sleep, potentially allowing cerebrospinal fluid to circulate more freely and transport metabolic waste. This process, called glymphatic drainage, may influence brain health, memory, and the accumulation of proteins associated with Alzheimer's disease. Discover what the research reveals about the brain's remarkable nighttime housekeeping system.

David Stephen Klein, MD FACA FACPM
Oct 2811 min read


Does Your Brain Actually Shrink During Sleep? Understanding Glymphatic Drainage. Alzheimers Prevention?
Glymphatic Drainage, Glymphatic System, Brain Health, Brain Aging, Cognitive Health, Alzheimer's Disease, Dementia Prevention, Neurodegenerative Disease, Sleep Health, Deep Sleep, Restorative Sleep, Sleep Quality, Sleep Disorders, Memory and Cognition, Healthy Aging, Longevity Medicine, Functional Medicine, Integrative Medicine, Preventive Medicine, Metabolic Health, Brain Waste Clearance, Cerebrospinal Fluid, Brain Shrinkage During Sleep, Amyloid Beta Clearance, Tau Protein,

David Stephen Klein, MD FACA FACPM
Oct 249 min read


Can Ferrous Sulfate Raise Ferritin? When Iron Supplements Help—or Hurt. Low Ferritin?
Can ferrous sulfate raise ferritin levels? Learn how oral iron supplements replenish iron stores, how hepcidin regulates absorption, and why low ferritin may contribute to fatigue and hair loss. Discover when iron supplementation is beneficial, why increasing ferritin does not guarantee hair regrowth, and the potential risks of unnecessary iron therapy. Understanding the cause of low ferritin is essential to choosing safe, effective treatment.

David Stephen Klein, MD FACA FACPM
Oct 219 min read


The Long Shadow of Influenza: Can the Flu Affect the Brain Decades Later? Trigger Dementia?
Influenza usually lasts days or weeks—but could its effects on the brain last much longer? From von Economo's mysterious encephalitis lethargica to modern research linking severe infections with neuroinflammation and later dementia, scientists are reconsidering the long-term neurologic consequences of infection. The evidence does not prove that influenza causes dementia, but it raises an important question: can infection alter the trajectory of an aging brain?

David Stephen Klein, MD FACA FACPM
Oct 713 min read


Your Fasting Glucose Is Normal—but Is Your Insulin?
A normal fasting glucose does not always mean normal metabolic health. During early insulin resistance, the pancreas may compensate by producing more insulin, keeping glucose deceptively normal. Measuring fasting insulin alongside glucose may reveal this hidden metabolic stress earlier. Learn why fasting insulin, HOMA-IR, A1c, triglycerides, waist circumference, and other markers can provide a more complete picture of insulin resistance and metabolic health.

David Stephen Klein, MD FACA FACPM
Sep 298 min read


Pulse Pressure, Aging, and Stroke Risk: Why the “Ideal” Number Changes With Age
Pulse pressure is the difference between systolic and diastolic blood pressure. For example, 120/80 mmHg produces a pulse pressure of 40 mmHg. Pulse pressure often widens with age as large arteries become stiffer. In older adults, a persistently wide pulse pressure may indicate increased arterial stiffness and cardiovascular risk, including stroke risk. It should be interpreted together with age, systolic and diastolic pressures, medical conditions, and overall cardiovascular

David Stephen Klein, MD FACA FACPM
Aug 149 min read


The Longevity Pulse: What Your Resting Heart Rate Says About Your Health
Your resting heart rate is more than just a number—it is a powerful biomarker of cardiovascular fitness, autonomic nervous system balance, metabolic health, and healthy aging. Learn why "normal" may not always mean "optimal," what research reveals about heart rate and longevity, and how exercise, sleep, nutrition, stress management, and overall health influence your pulse. Discover practical strategies to improve cardiovascular efficiency and support a longer, healthier life.

David Stephen Klein, MD FACA FACPM
Aug 1010 min read


C15:0 (Pentadecanoic Acid): Could This Be the First Newly Recognized Essential Fatty Acid in Nearly 100 Years?
Could C15:0 (pentadecanoic acid) become the first newly recognized essential fatty acid in nearly a century? Emerging research suggests this naturally occurring odd-chain saturated fatty acid may support healthy cell membranes, mitochondrial function, metabolic health, and healthy aging. Learn what current science tells us about food sources, supplements, recommended intake, and why researchers are paying close attention to this unique nutrient.

David Stephen Klein, MD FACA FACPM
Aug 77 min read
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