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Microplastics and Human Health: What Medicine Is Beginning to Understand.
Microplastics and nanoplastics have emerged as a previously unrecognized but increasingly relevant source of chronic environmental exposure. Once thought to be biologically inert, these particles—derived from degraded consumer plastics and industrial materials—are now routinely detected in human blood, stool, lung tissue, placenta, breast milk, and even atherosclerotic plaques. Their presence in these tissues challenges long-standing assumptions about plastic safety and raise

David S. Klein, MD FACA FACPM
4 days ago5 min read


Medicare Advantage Plans: What Patients Gain, What They Lose, Limitations, and Why It Matters
Medicare Advantage plans often advertise low premiums and extra benefits, but their structure can quietly limit access to physician-directed care. Through restricted networks, prior authorization, and administrative denials, patients may lose control precisely when medical complexity increases. This physician-led guide explains what Medicare Advantage plans do well, where they fall short, and why understanding these tradeoffs before enrollment matters.
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David Stephen Klein, MD FACA FACPM
5 days ago4 min read


Is It Dementia — or Is It Something Else? Medical Conditions That Can Mimic Dementia and Cognitive Decline
Is It Dementia — or Is It Something Else?
Cognitive decline is frequently assumed to represent dementia, yet a wide range of medical conditions can closely mimic neurodegenerative disease and are often treatable when identified early. Acute delirium, commonly triggered by infection, dehydration, metabolic abnormalities, or medication effects, is one of the most frequently missed causes of sudden confusion and cognitive change. Medications themselves, particularly anticholiner

David S. Klein, MD FACA FACPM
Jan 265 min read


Uric Acid and Colorectal Cancer: An Emerging Predictive Biomarker
Elevated uric acid is more than a marker for gout. Growing evidence suggests it reflects metabolic inflammation and oxidative stress linked to increased colorectal cancer risk. This physician-led review explores how uric acid functions as a predictive biomarker, its relationship to insulin resistance and chronic inflammation, and how average-risk screening tools like Cologuard fit into a modern preventive care strategy focused on early detection and risk reduction.

David S. Klein, MD FACA FACPM
Jan 255 min read


Vitamin D is a Hormone
Vitamin D is commonly thought of as a simple nutrient, but medically it functions as a steroid hormone with effects far beyond bone health. Unlike true vitamins, vitamin D is synthesized in the skin, activated through the liver and kidneys, and acts on receptors throughout the body to regulate gene expression. This hormonal role explains its influence on immune function, muscle strength, cardiovascular health, and brain function. Because deficiency is widespread and supplemen

David S. Klein, MD FACA FACPM
Jan 244 min read


St. John's Wort: Why This "Natural" Supplement Can Be Medically Dangerous
St. John’s wort is often viewed as a safe, natural supplement, but it is one of the most dangerous herbal products when combined with prescription medications. By strongly inducing liver enzymes and drug transporters, it can lower blood levels of antidepressants, birth control pills, anticoagulants, and transplant medications—sometimes leading to serotonin syndrome, unintended pregnancy, stroke, or organ rejection.

David S. Klein, MD FACA FACPM
Jan 204 min read


Advanced Glycation End Products (AGEs):
Advanced glycation end products (AGEs) are biologically active compounds formed through non-enzymatic reactions between sugars and proteins, lipids, or nucleic acids. While AGE accumulation is a normal feature of aging, modern dietary patterns, insulin resistance, oxidative stress, and chronic hyperglycemia markedly accelerate their formation. Increasing evidence identifies AGEs as a central and under-recognized contributor to atherosclerotic cardiovascular disease (ASCVD) an

David S. Klein, MD FACA FACPM
Jan 164 min read


Influenza A and B Outbreaks: Why the Flu Season Comes in Waves
This year’s influenza season has followed a familiar clinical pattern, with an early surge of Influenza A infections followed by a later rise in Influenza B cases. While Influenza A is often associated with more severe illness and higher early hospitalization rates, Influenza B can extend the flu season and cause significant disease, particularly in children and older adults. Understanding this progression helps explain why flu activity persists later into the season and unde

David S. Klein, MD FACA FACPM
Jan 153 min read


Migraine vs Sinus Headache
Migraines and sinus headaches are often confused because they can share facial pain, congestion, and watery eyes—but they are fundamentally different conditions that require different treatments. Migraines are a neurological disorder commonly associated with throbbing head pain, nausea, and sensitivity to light and sound, while true sinus headaches result from inflamed or infected sinus cavities and are typically accompanied by thick nasal discharge, fever, and pain that wors

David S. Klein, MD FACA FACPM
Jan 85 min read


THC, REM Sleep, and the Quiet Disruption of Sleep Architecture
THC may shorten sleep onset, but research shows it suppresses REM sleep and disrupts normal sleep architecture. Over time, this can impair memory, mood, and restorative sleep—especially with nightly use. Understanding the difference between sedation and healthy sleep is critical.

David S. Klein, MD FACA FACPM
Jan 55 min read
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