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Sepsis and the Urinary Tract: Why Diagnosis Fails—And How We Fix It
Sepsis frequently originates from urinary infections in older adults, yet diagnosis is often flawed. Routine dipsticks can miss true infection and overcall colonization. This article explains the limitations of traditional testing and introduces a more accurate strategy: urinalysis with culture, followed by PCR when needed. Early recognition and improved diagnostics can significantly alter outcomes.

David Stephen Klein, MD FACA FACPM
Apr 295 min read


Avoid Vitamin D2, use Vitamin D3
Vitamin D supplements are not interchangeable, and the distinction between vitamin D₂ (ergocalciferol) and vitamin D₃ (cholecalciferol) has real clinical consequences. Although both forms can raise measured vitamin D levels, vitamin D₃ is more potent, more stable, longer lasting, and biologically identical to the hormone the human body naturally produces. In contrast, vitamin D₂ is less effective, clears more rapidly, and may even suppress circulating vitamin D₃, undermining

David S. Klein, MD FACA FACPM
Apr 224 min read


Bacteria in the Urine: When Not Treating Is Safe—And When It Is Not
Bacteria in the urine does not always require treatment—but failing to treat a true infection can be dangerous. This article explains when bacteriuria can be safely observed and when it must be treated to prevent complications such as kidney infection, bacteremia, and sepsis.

David Stephen Klein, MD FACA FACPM
Apr 174 min read
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