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Uric Acid and Longevity: Live Longer by Keeping the Level below 5.5 mg/dl
Most people associate uric acid with gout, but emerging research suggests it may be far more important. Elevated uric acid has been linked to hypertension, cardiovascular disease, kidney disease, insulin resistance, endothelial dysfunction, and accelerated aging. While many laboratories consider levels up to 7.0 mg/dL “normal,” evidence suggests that levels below 5.5 mg/dL—and ideally near 5.0 mg/dL—may provide greater protection against vascular injury and chronic disease. U

David Stephen Klein, MD FACA FACPM
Jun 166 min read


Uric Acid and Nitric Oxide: The Hidden Driver of Endothelial Dysfunction and Vascular Disease
Uric acid does more than cause gout—it reduces nitric oxide, impairing blood vessel function and increasing risk for hypertension, heart disease, and kidney dysfunction. Understanding this connection allows earlier intervention and better long-term outcomes.

David Stephen Klein, MD FACA FACPM
Apr 115 min read
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