Uric acid is best known for gout, but elevated levels are also associated with hypertension, kidney dysfunction, and cardiovascular risk. Research suggests that uric acid may influence blood pressure through oxidative stress, reduced nitric oxide, renin-angiotensin activation, renal vasoconstriction, and altered sodium handling. Learn how uric acid, kidney function, and hypertension may form a self-reinforcing cycle—and why lowering uric acid is not always the same as lowerin

Creatine is widely used to improve muscle mass and athletic performance, but it may not be appropriate for everyone. While generally considered safe in healthy individuals, concerns remain for patients with kidney disease, diabetes, hypertension, dehydration, or those taking medications that affect renal function. This article reviews potential risks, explains who should exercise caution, and discusses safer alternatives for preserving muscle mass and healthy aging.