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Low-Dose Lithium for Mild to Moderate Depression: Can a Time-Tested Mineral Improve Mood, Protect the Brain, and Promote Healthy Aging?
Could a medication long used for bipolar disorder also help support mood, protect the brain, and promote healthy aging at much lower doses? Emerging research suggests low-dose lithium may enhance neuroplasticity, reduce neuroinflammation, improve mitochondrial function, and influence pathways involved in depression and cognitive decline. Learn the current science, safety considerations, and how a systems-based evaluation may improve outcomes.

David Stephen Klein, MD FACA FACPM
Jul 2812 min read


Alpha-Lipoic Acid: A Powerful Tool for Metabolic Health, Weight Loss, Insulin Resistance and Brain Protection
Alpha-lipoic acid (ALA) is a powerful antioxidant that plays an important role in metabolism, weight management, and brain health. Research shows it may improve insulin sensitivity, support healthy blood sugar regulation, promote fat metabolism, and help protect against cognitive decline by reducing oxidative stress and improving mitochondrial function. For patients focused on longevity and prevention, ALA may represent one of the most versatile evidence-based nutritional int

David Stephen Klein, MD FACA FACPM
Jul 165 min read


Can a Simple CBC Predict Future Dementia Risk?
The Monocyte-to-Lymphocyte Ratio and Its Emerging Role in Cognitive Decline. One of the cheapest test that is currently available. Can a Simple CBC Predict Future Dementia Risk? Understanding how the Monocyte-to-Lymphocyte Ratio (MLR) may reveal early inflammatory changes associated with Alzheimer’s disease, vascular dementia, and accelerated cognitive aging. Quick Look Could a routine complete blood count reveal early warning signs of future dementia? A growing body of evide

David Stephen Klein, MD FACA FACPM
Jul 75 min read


Vitamin D in Midlife May Reduce Future Tau Protein Burden: Implications for Dementia Prevention
A major new study published in Neurology demonstrated that individuals with higher circulating vitamin D levels during midlife showed significantly lower tau protein accumulation in the brain nearly two decades later. Tau protein accumulation is one of the central pathological hallmarks of Alzheimer’s disease and other neurodegenerative disorders. These findings suggest vitamin D optimization during midlife may represent an overlooked but potentially powerful intervention for

David Stephen Klein, MD FACA FACPM
Jun 156 min read


Hearing Loss and Your Brain. Why Getting Hearing Aids Now Can Help Protect You From Dementia
Untreated hearing loss increases the risk of dementia by straining the brain and promoting social isolation. Early hearing-aid use helps preserve cognition and quality of life.

David S. Klein, MD FACA FACPM
Nov 18, 20257 min read


The Benefits of Lithium: An Emerging Role in Memory Loss & Alzheimer’s Prevention and Treatment
Low dose lithium may be a useful tool in the treatment and prevention of memory loss and alzheimer's disease. Well below the dosages used to treat psychiatric disorders, low dose lithium may provide symptomatic relief and may forestall or prevent the development of age related memory loss and dementia.

David S. Klein, MD FACA FACPM
Aug 19, 20255 min read
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