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Magnesium Deficiency: The Overlooked Driver of Arrhythmia, Insulin Resistance, and Anxiety
Magnesium deficiency is common and often missed. Low magnesium contributes to arrhythmias, insulin resistance, anxiety, and metabolic dysfunction—frequently despite “normal” serum labs. Learn how magnesium affects cardiac stability, insulin signaling, and neuroexcitation, and why correcting intracellular deficiency may improve cardiometabolic and neurologic health.

David Stephen Klein, MD FACA FACPM
Feb 204 min read


Measles Resurgence in Florida: Understanding the Risks, Prevention, and Cost–Benefit of Vaccination
Recent measles cases in Florida underscore how quickly this highly contagious virus can spread when vaccination rates decline. Measles carries significant risks including pneumonia and encephalitis, and outbreaks impose substantial public health costs. The MMR vaccine remains a highly effective and economically sound preventive strategy that protects individuals and vulnerable communities.

David Stephen Klein, MD FACA FACPM
Feb 195 min read


Hyperinsulinemia: The Metabolic Condition We Rarely Diagnose- but Routinely Treat Too Late
Hyperinsulinemia often precedes diabetes by decades, quietly driving heart disease, weight gain, hypertension, fatty liver disease, and accelerated aging—even when glucose levels appear normal. Early detection shifts care from reactive treatment to true prevention.

David S. Klein, MD FACA FACPM
Feb 134 min read


Microplastics and Human Health: What Medicine Is Beginning to Understand.
Microplastics and nanoplastics have emerged as a previously unrecognized but increasingly relevant source of chronic environmental exposure. Once thought to be biologically inert, these particles—derived from degraded consumer plastics and industrial materials—are now routinely detected in human blood, stool, lung tissue, placenta, breast milk, and even atherosclerotic plaques. Their presence in these tissues challenges long-standing assumptions about plastic safety and raise

David S. Klein, MD FACA FACPM
Feb 35 min read


Medicare Advantage Plans: What Patients Gain, What They Lose, Limitations, and Why It Matters
Medicare Advantage plans often advertise low premiums and extra benefits, but their structure can quietly limit access to physician-directed care. Through restricted networks, prior authorization, and administrative denials, patients may lose control precisely when medical complexity increases. This physician-led guide explains what Medicare Advantage plans do well, where they fall short, and why understanding these tradeoffs before enrollment matters.
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David Stephen Klein, MD FACA FACPM
Feb 14 min read


Is It Dementia — or Is It Something Else? Medical Conditions That Can Mimic Dementia and Cognitive Decline
Is It Dementia — or Is It Something Else?
Cognitive decline is frequently assumed to represent dementia, yet a wide range of medical conditions can closely mimic neurodegenerative disease and are often treatable when identified early. Acute delirium, commonly triggered by infection, dehydration, metabolic abnormalities, or medication effects, is one of the most frequently missed causes of sudden confusion and cognitive change. Medications themselves, particularly anticholiner

David S. Klein, MD FACA FACPM
Jan 265 min read


Uric Acid and Colorectal Cancer: An Emerging Predictive Biomarker
Elevated uric acid is more than a marker for gout. Growing evidence suggests it reflects metabolic inflammation and oxidative stress linked to increased colorectal cancer risk. This physician-led review explores how uric acid functions as a predictive biomarker, its relationship to insulin resistance and chronic inflammation, and how average-risk screening tools like Cologuard fit into a modern preventive care strategy focused on early detection and risk reduction.

David S. Klein, MD FACA FACPM
Jan 255 min read


Vitamin D is a Hormone
Vitamin D is commonly thought of as a simple nutrient, but medically it functions as a steroid hormone with effects far beyond bone health. Unlike true vitamins, vitamin D is synthesized in the skin, activated through the liver and kidneys, and acts on receptors throughout the body to regulate gene expression. This hormonal role explains its influence on immune function, muscle strength, cardiovascular health, and brain function. Because deficiency is widespread and supplemen

David S. Klein, MD FACA FACPM
Jan 244 min read


St. John's Wort: Why This "Natural" Supplement Can Be Medically Dangerous
St. John’s wort is often viewed as a safe, natural supplement, but it is one of the most dangerous herbal products when combined with prescription medications. By strongly inducing liver enzymes and drug transporters, it can lower blood levels of antidepressants, birth control pills, anticoagulants, and transplant medications—sometimes leading to serotonin syndrome, unintended pregnancy, stroke, or organ rejection.

David S. Klein, MD FACA FACPM
Jan 204 min read


Advanced Glycation End Products (AGEs):
Advanced glycation end products (AGEs) are biologically active compounds formed through non-enzymatic reactions between sugars and proteins, lipids, or nucleic acids. While AGE accumulation is a normal feature of aging, modern dietary patterns, insulin resistance, oxidative stress, and chronic hyperglycemia markedly accelerate their formation. Increasing evidence identifies AGEs as a central and under-recognized contributor to atherosclerotic cardiovascular disease (ASCVD) an

David S. Klein, MD FACA FACPM
Jan 164 min read
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