Advanced glycation end products (AGEs) are biologically active compounds formed through non-enzymatic reactions between sugars and proteins, lipids, or nucleic acids. While AGE accumulation is a normal feature of aging, modern dietary patterns, insulin resistance, oxidative stress, and chronic hyperglycemia markedly accelerate their formation. Increasing evidence identifies AGEs as a central and under-recognized contributor to atherosclerotic cardiovascular disease (ASCVD) an