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Uric Acid and Hypertension: Is Your Uric Acid Helping Drive Your Blood Pressure?
Uric acid is best known for gout, but elevated levels are also associated with hypertension, kidney dysfunction, and cardiovascular risk. Research suggests that uric acid may influence blood pressure through oxidative stress, reduced nitric oxide, renin-angiotensin activation, renal vasoconstriction, and altered sodium handling. Learn how uric acid, kidney function, and hypertension may form a self-reinforcing cycle—and why lowering uric acid is not always the same as lowerin

David Stephen Klein, MD FACA FACPM
Aug 179 min read


Pulse Pressure, Aging, and Stroke Risk: Why the “Ideal” Number Changes With Age
Pulse pressure is the difference between systolic and diastolic blood pressure. For example, 120/80 mmHg produces a pulse pressure of 40 mmHg. Pulse pressure often widens with age as large arteries become stiffer. In older adults, a persistently wide pulse pressure may indicate increased arterial stiffness and cardiovascular risk, including stroke risk. It should be interpreted together with age, systolic and diastolic pressures, medical conditions, and overall cardiovascular

David Stephen Klein, MD FACA FACPM
Aug 149 min read


Understanding the Connection Between Hypothyroidism and Atherosclerotic Heart Disease
Hypothyroidism is far more than a problem of low metabolism—it’s a quiet amplifier of vascular disease. By addressing thyroid imbalance, we not only restore energy and mental clarity but also protect the heart from atherosclerotic injury. Managing these conditions together yields the best outcomes for long-term vitality and longevity.

David S. Klein, MD FACA FACPM
Nov 13, 20255 min read
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